Senior / Staff Scientist, Antibody Development

Job Description
About the Role:

We are seeking a strong scientific contributor to join the New Product Development team to contribute and lead the development and technology transfer of antibody content from early stage research into manufacturing and production.

The New Product Development team at 10X Genomics acts as the interface between early stage R&D and production and this position would interact directly with both of these organizations. This is a cross-disciplinary position that will work closely with groups across 10X that include Molecular Biology, Computational Biology, Quality Control, and Manufacturing to develop and validate antibody based reagents for the rapid expansion of 10X’s portfolio.

In addition to deep knowledge and experience with antibodies, candidates must also have a broad working knowledge of molecular biology or biochemistry and be able to apply that knowledge independently and creatively toward the development of novel NGS and in situ products. Previous experience with custom formulation and application of antibodies for product development that includes late stage development, quality control assays, successful product launches, and ongoing product support is essential.

The successful applicant will have exceptional attention to detail and the ability to design, execute, and analyze highly complex experiments. Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast paced environment, excel at managing priorities, and provide clear communication and recommendations around scientific results.

 

What you will be doing:

Actively contribute to the development of single cell, spatial, and in situ products from early concept through post-launch and sustaining activities for antibody custom content.
Provide technical leadership in the lab to develop and evaluate workflows for custom antibody applications, formulations, and ongoing product support across multiple product lines.
Guide infrastructure development projects that would enable and enhance 10x’s ability to deliver antibody based catalog and custom content across multiple product lines.
Interact and establish healthy long term relationships with external vendors.
Evaluate and transfer critical technologies for antibody conjugation and/or labeling.
Identify, hire, and lead exceptional personnel for ongoing antibody development projects.
Independently troubleshoot and resolve issues around antibody formulation, long term storage, and quality control issues.
Conceive, develop, validate, and implement new QC methods to assess formulations of single and complex antibody blends.
Design and conduct experiments to determine understanding of antibody interactions within complex systems, cause & effect, failure modes, guard band studies, and optimization using DOE methodologies.

Minimum Requirements:

PhD or MS in Molecular Biology, Biochemistry, Genetics, Microbiology, Cell biology, Immunology, Protein/Antibody Engineering, or related fields.
7+ years (PhD) or 11+ years (MS) of relevant Biotechnology industry experience.
Deep understanding of and hands-on experience with antibody expression, purification, analytical applications, quality control, formulation for stability and/or performance, and product development.
Demonstrated success in developing, optimizing, and troubleshooting antibody panels for novel analytical assays.
Experience developing and implementing novel QC methods to assess performance of antibody panels in both functional and orthogonal assays.
Experience with antibody conjugation chemistries and their quantification.
Ability to write standard operating procedures (SOPs) and train others to successfully plan, execute, and evaluate complex analytical assays.
Demonstrate exceptionally strong collaboration and communication skills across technical and non-technical parts of an organization.
Product development experience demonstrated by the successful launch of a commercial product where antibodies play a critical technical role.

Preferred Skills/Experience:

Previous experience supervising and/or mentoring junior staff
Able to demonstrate leadership and success guiding antibody based products from concept phase through launch.
Exposure to working with antibody panels in the context of fixed tissue samples.
Expertise in antibody screening and relevant experimental workflows.
Previous work with custom reagent vendors and setting up long term OEM relationships.
Experience defining and transferring workflows for custom product formulation.
Experience using statistical tools, such as JMP or R to analyze complex data sets, create DOE experiments, and data trending.
Hands-on experience with 10X single cell or spatial products.

 

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About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

To apply for this job please visit 10xgenomics.eightfold.ai.

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