Lead Scientist, Process Chemistry

Our mission at Ansa Biotechnologies is to revolutionize the way we make DNA. Compared to reading or editing life’s code, writing new code from scratch has remained one of the field’s most elusive challenges. At Ansa, we are putting nature to work, creating novel enzymatic solutions that will redefine how we build DNA. We believe that the biggest challenges our world faces will be solved using biotechnology and that DNA synthesis is the fuel for that transformation. Our enzyme-based approach (published in Nature Biotechnology) promises to dramatically accelerate innovation in biological research and biotechnology, including therapeutics, diagnostics, biomanufacturing, and synthetic biology.

One of the key benefits of our approach to synthesizing DNA with enzyme-nucleotide conjugates, is efficiency, which translates to cost reduction. We believe this will result in broadening the overall accessibility of high quality synthetic DNA to the world. The efficient production of our modified nucleotides, designed specifically for the needs of the Ansa DNA synthesis platform, is essential for realizing this promise of our technology. This role will spearhead these efforts, building and managing a team focused on scalable process optimization and execution, making key decisions that will have company level impact.

If you feel the satisfaction of working with others to develop efficient and robust processes to deliver large quantities of high quality nucleotides, we have a great opportunity for you!

 

Responsibilities

Collaborating in a team environment: At Ansa, communication between teams is critical–our technology is built on enzymes, chemistry, and automation. Additionally, we believe that honesty and openness are an instrumental part of the scientific endeavor.
Being a team leader: provide guidance and career development to an interdisciplinary team of chemists. Assist your fellow scientists with constructive criticism and feedback.
Design, execute, and scale synthetic routes to produce large quantities of modified nucleotides with extremely high purity.
Work with other teams to determine company wide needs for modified nucleotides and manage their production to meet these needs.
Experience

PhD in Chemistry, or equivalent
5+ years experience with organic chemistry and nucleic acid chemistry
Strong organic chemistry background
Extensive hands-on experience with nucleoside/nucleotide synthesis
Large scale nucleotide purifications (reverse phase and ion exchange) is a plus
Strong analytical chemistry skills with exposure to modern spectroscopic and chromatographic methods (ie HPLC, UHPLC-MS, NMR)
Experience with development and maintenance of QC pipelines and document tracking
Extremely high attention to detail
Ability to learn quickly and thrive in a fast-paced, multidisciplinary environment
Leadership and management philosophy in alignment with the goals and culture of the company
Strong interpersonal, verbal communication, and presentation skills
if you would like to learn more about this role, please email our recruiting team at careers@ansabio.com.

To apply for this job please visit ansabio.com.

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