Scientist, CAR-NK Therapeutics

We are seeking an energetic Scientist to join our Stem Cell Therapeutics team. You will closely collaborative with other Scientists and Research Associates to drive discovery and the development of Caribou’s first iPSC-derived NK (iNK) cell therapy product. You’ll apply your expertise in immunology to generate engineered iNK cells with enhanced function and persistence using Caribou’s chRDNA genome editing platform. This is a wonderful opportunity to be involved with the development of next-generation therapies and advance them into the clinic while growing with a team who are generous with their time, always willing to give advice to help with challenging experiments, and who are there to celebrate your wins.

Responsibilities:

Design and evaluate chimeric antigen receptors (CAR) and other armoring strategies in iNK cells to optimize tumor cell killing activity
Collaborate with the pharmacology group to perform in vivo studies to evaluate CAR-iNK cell persistence and anti-tumor killing activity
Manage Research Associate(s) within the team
Coordinate experiments with other Scientists and RAs across functional groups, compile data and present results and stay current on relevant primary literature
Data analysis and communicate scientific data and concepts effectively through presentations, protocols, test methods and reports
Qualifications:

PhD in Immunology or related discipline
Minimum of 2 years of relevant post-doctoral academic or industry experience
Strong background in immunology with experience in NK and/or CAR-T based cancer therapy
Expertise in developing and executing in vitro cellular characterization assays including immune cell phenotyping, cytotoxicity, proliferation, migration, and cytokine analysis.
Hands on experience engineering immune cells and/or iPSC with genome-editing technologies
Excellent verbal and written communication skills
Proven ability to work independently, as well as to collaborate with peers and work effectively in a fast-paced team-oriented environment
Strong organizational, time management, communication and interpersonal skills
Nice-to-have:

Experience with differentiation of pluripotent stem cells into immune cells (e.g. NK, T, Macrophages)
Experience in retroviral/lentiviral transduction of immune cells
Experience with robotic cell culture automation and performing high-throughput screening assays
Fluorescence microscopy & imaging analysis experience
Caribou compensation and benefits include:

Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
Generous paid vacation time, in addition to company-observed holidays and floating holidays
Excellent medical, dental, and vision insurance
401(k) retirement savings plan, which includes matching employer contributions
Tuition reimbursement program
Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.

For more information about Caribou, visit www.cariboubio.com and follow the company @CaribouBio.

To apply for this job please visit boards.greenhouse.io.

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