Senior Research Associate, Platform Discovery

As a result of exciting developments both with Caribou’s internal pipeline programs and our external partnership, we have multiple early-stage projects at Caribou focused on the preclinical discovery and development of CAR-T cell therapy candidates. We are looking for an independent, goal-oriented Senior Research Associate to help us propel this work forward. This is an exciting and challenging role in which you will lend your molecular and cell biology expertise to support a variety of research and development projects. The ideal motivated and enthusiastic candidate will work collaboratively and cross-functionally with multiple researchers on cutting-edge technologies to deliver on impactful research projects that we believe will ultimately positively impact the lives of patients.

Responsibilities include:

Designing and performing Array of molecular biology techniques including primer design, PCR, in vitro transcription, plasmid design and cloning, small- and large-scale plasmid preparation
Culturing primary human T cells, including isolation, activation and expansion from peripheral blood mononuclear cells
Gene editing and manipulation of primary cells using nucleofection and viral transduction
Analyzing gene editing outcomes by sequencing and flow-based methodologies
Coordinating experiments with other Scientists and RAs across functional groups
Compiling data, presenting results, and staying current on relevant literature

Bachelor’s degree, Master’s degree or equivalent experience in Cell Biology, Immunology, Biochemistry, Molecular Biology, or related discipline
Minimum of 5 years of experience designing, performing and troubleshooting molecular and cell assays
Experience with a variety of molecular techniques such as PCR, cloning, and in vitro transcription
Experience in mammalian cell culture techniques; working with and manipulating multiple cell lines and primary human cells; demonstrated ability to develop cell handling protocol
Willingness and ability to share occasional weekend cell culture duties

Competency in flow cytometry
Competency with molecular biology design tools
Background in immunology or oncology
Familiarity with mammalian cell culture techniques
Application of genome editing technologies
Experience working with a wide array of primary cells (including iPSC and NK cells) and cell lines
Caribou compensation and benefits include:

Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
Generous paid vacation time, in addition to company-observed holidays and floating holidays
Excellent medical, dental, and vision insurance
401(k) retirement savings plan, which includes matching employer contributions
Tuition reimbursement program
Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.

For more information about Caribou, visit and follow the company @CaribouBio.

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