Senior Scientist/Principal Scientist, Preclinical Pharmacology

We are currently seeking an enthusiastic Senior Scientist/Principal Scientist with a strong background in cancer immunotherapy to join our Pharmacology team. As a member of a highly collaborative team, you will interact and work closely with researchers from Pharmacology and other functional areas to help progress our therapeutic pipeline into the clinic. The successful candidate should be experienced in preclinical pharmacology research and be able to oversee daily research activities at both scientific and technical levels. In this role, the candidate will report to the VP of Pharmacology.


Participate in the design, planning and execution of experiments to evaluate and elucidate in vivo anti-tumor efficacy, safety, mechanism of action, trafficking, biodistribution and persistence, as well as biomarker discovery of therapeutic candidates
Coordinate team efforts and participate in animal model development and data generation, interpretation, and reporting
Perform hands-on work when needed, including animal modeling, ex vivo analyses, as well as in vitro assays, where required
Serve as a subject matter expert (SME) in internal scientific discussions, project meetings and external collaborations. Prepare presentations and data summaries for internal and external meetings, regulatory filings and publications
Oversee CRO activities when needed
Provide input for scientific discussions and conception of new research approaches. Contribute intellectually to the organization’s success
Manage and direct daily work of junior research staff
Maintain detailed documentation of data and procedures in compliance with internal policy

Doctorate degree in Immunology or relevant biological sciences with an immuno-oncology research background, ideally in the immune cell therapy field
8+ years of postdoctoral research experience in biological research, with a minimum of 3 years of drug development experience in an industry setting
Extensive exposure in preclinical murine models, particularly oncology models, such as xenograft, PDX, and/or syngeneic models is required
Must demonstrate experience and technical excellence in in vivo experiments in oncology research
Hands-on experience with in vivo bioluminescence and/or fluorescence imaging workflow and data analysis is preferred.
Previous hands-on experience in multi-color flow cytometry and data analysis, as well as exposure to in vitro cell-based assays are required
Working knowledge of immunohistochemistry and data interpretation is a plus
Previous management experience is required
Demonstrated scientific creativity, critical thinking, and analytical problem-solving skills, with a track record of research productivity as evidenced by first/last author publications
Ability to work efficiently and independently under minimal supervision with strong organizational and record-keeping skills
Excellent written and verbal communication skills
Caribou compensation and benefits include:

Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
Generous paid vacation time, in addition to company-observed holidays and floating holidays
Excellent medical, dental, and vision insurance
401(k) retirement savings plan, which includes matching employer contributions
Tuition reimbursement program
Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.

For more information about Caribou, visit and follow the company @CaribouBio.

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