Scientist/Senior Scientist – Protein Sequencing Assay Platform Development

Encodia, Inc.

Empowering Proteomics

About Encodia

Encodia is a rapidly growing platform company that is developing a new generation of protein analysis tools based on single-molecule protein sequencing. Our goal is to make protein sequencing easy and ubiquitous by using a novel reverse-translation technology that turns peptide sequences into DNA. The DNA can be read by a DNA sequencer, providing a path to breakthrough proteomics research at a scale that is not practical or cost-effective using current technologies.

Job Summary

We are seeking an experienced molecular biologist to develop novel, highly multiplexed assays. The ideal candidate will have a strong quantitative analytical skill set and deep expertise in designing, developing, optimizing and troubleshooting high-plex molecular assays and systems. Only highly motivated candidates with a passion for innovation are encouraged to apply.

Job Responsibilities

  • Participating in the development of a cutting-edge protein analysis platform.
  • Working at the interface of nucleic acid and protein biochemistry including characterization of enzymatic and binding reactions to mature assay technology.
  • Designing and developing production-level measurement systems and quality controls.
  • Collaborating cross functionally to develop essential processes.
  • Analyzing and interpreting data to troubleshoot and optimize assay performance.


  • Ph.D. with 4+ years’ of experience in Molecular Biology, Biochemistry, Chemical Biology or a related field.
  • Experience in developing multiplexed assay systems, with expertise in digital single-molecule assays a plus.
  • Expert knowledge and experience in using quantitative methods to dissect and optimize biomolecular assays, including measures of specificity, dynamic range, precision, and reproducibility.
  • Expert knowledge of molecular biology enzymes and their use in assay processes.
  • A strong technical foundation in analytical techniques for characterizing nucleic acids and proteins.
  • Experience in use of high-throughput automation for assay optimization a plus.
  • Knowledge of statistical process control tools (gage R&R, control charts, Six Sigma, DOE) and related software (JMP, Minitab) preferred.
  • Excellent teamwork and written/oral communication across all levels of the organization.

Tagged as: next-gen proteomics assays, NGS, nucleic acid enzymology, protein biochemistry, protein-small molecule interaction

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