Single Cell Scientist

Are you ready to tackle massive single cell sequencing experiments, testing hundreds of pooled interventions for therapeutic effects using a single animal? You’ll be at the center of a fast-paced team of scientific experts looking to run in vivo tests for more therapeutic targets than ever before, and generating high-quality single cell data from multiple species and tissues is essential for the company’s success.

Key Qualifications:

  • Solid foundation of animal work, including sacrifices and tissue extraction.
  • Years of experience doing single cell sequencing (RNA/ATAC), or other experiments where cell viability and yield is paramount.
  • Undaunted by long experimental protocols involving dozens of samples.
  • Process mindset, focused on reliability, optimization, and risk mitigation.
  • Experience or familiarity with flow cytometry.
  • Organized, good record keeper, and used to working in collaborative teams.

Bonus points for experience with immunology or non-cancer disease biology, working with large animal models or human tissues, Illumina sequencing, and/or single cell methods development.

The Company:
Gordian Biotechnology is a therapeutics company focused on diseases of aging, the major unmet medical need of our generation.
Age-related diseases have complex causes that include interactions with the aged environment, and traditional ex vivo screening methods have failed to produce effective treatments. In contrast, Gordian’s platform delivers and tests hundreds of therapeutics in individual animals to generate the most relevant preclinical datasets, at scale.

The Journey:
Our mission is ambitious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.

Team – Relying on each other begins with transparency. We set clear goals, visible to all, connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions with the bigger picture in mind. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help.

Extraordinary – Every day, we ask ourselves ‘could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. 

Like any cutting-edge research environment, Gordian doesn’t believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. Last year, in accordance with our unlimited vacation policy, each member took an average of 2.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by collaborative planning. If this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. 

You can dive deeper here: 

And you:
You have a history of successful execution, both in- and outside of your job description. You want a chance to do your best work, immerse yourself and excel, with people you’ll want to spend your days with.
You truly want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness.
You have experience managing time-sensitive projects, in collaboration with other specialists. You have deep expertise, and broad curiosity. You are excited to use and develop cutting-edge technology to advance biology and human health.

Your mission as Single Cell scientist is to ensure that Gordian’s screens result in high-quality data. Specifically, you will be leading our ‘tissue collection to next generation sequencing’ workflow. This involves designing and executing tissue collections from experimental animals, generating and sorting single-cell suspensions of these tissues, and preparing these sorted cells for next generation sequencing. Much of our work happens in large animal disease models, and you’ll need to produce great results from challenging (e.g. fibrotic) samples. You will be expected to take ownership of this part of our platform, including continuous optimization of protocols, application of new technologies and sequencing modalities, and development of methods required for us to work with new and difficult samples. You will thus be directly responsible for the scientific progress of the company. 
Each of the steps in our tissue collection to sequencing pipeline requires careful and timely execution, to capture accurate information from our multi-month experiments. You will be responsible for managing experimental schedules and sample databases for many parallel projects, including coordinating with our heads of disease biology, gene therapy, and bioinformatics, ensuring that each experiment is set up to generate the necessary data. Once data is generated, you will be actively involved in interpretation of this data, using your understanding of biology and the experimental workflows to inform future direction of these analyses.
When you start, our current Single Cell Scientist will train you in our optimized isolation protocols. You’ll use this foundation to prepare and validate protocols for three other cell type/tissue combinations in your first three months, reaching yields equivalent to established protocols. Moving forward you will continue generating high quality data while also adopting new single cell methods for use in our platform, reporting to the Head of Platform, and guiding single cell project planning alongside our gene therapy and molecular biology teams.

The Details:
Gordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in South San Francisco.

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