Nucleic Acid Delivery Scientist

  • Full Time
  • San Diego
  • Posted 1 month ago
  • Work Visa Required

Molecular Axiom, LLC.

Our innovation is someone's hope

Who are you?

As a Nucleic Acid Delivery Scientist, you will produce and optimize formulations with nucleic acid payload to enable in vitro and in vivo evaluation of the delivery vehicles. You will also characterize the delivery vehicles with various analytical methods, including size, surface charge and encapsulation efficiency measurements. You will dissect the manufacturing process, and are expected to be able to perfect the steps to meet the acceptance criteria consistently, help the scale up process, and perform technology transfer to CMOs. You will work closely with the internal team to enable in vitro and in vivo evaluation and identify innovative technologies externally to create novel vehicles. Your ultimate goal is to leverage your experience and knowledge to help Molecular Axiom advance nucleic acid-based therapies into clinical development.

We’re looking for candidates who have a can-do attitude and embrace and thrive in our vibrant and collaborative start-up culture. You are not only expected to be an independent scientific contributor, but also a ready collaborator with your teammates. You will speak up in team discussions and participate in the decision-making process. You must be willing to lead and be led, help, and be helped, and enjoy the close professional relationships at work striving to achieve the company’s objectives and vision.

Responsibilities including, but not limited to:

  • Produce formulations for various nucleic acid payloads. Prepare test articles for animal studies and characterize the formulations pre- and post- dosing to ensure study quality.
  • Work with in vivo scientists to design the Pharmacology and DMPK studies, and forecast and manage material requirements and timelines.
  • Analyze the data and present the formulation work in meetings and identify potential modifications to improve the function of the vehicles.
  • Identify potential and promising nucleic acid technologies, verify the validity experimentally, and recommend to management a path forward.
  • Author technology reports and SOPs and manage technology establishment and transfer to facilitate project progression.

Requirements & Technical Skills:

  • Degree in Biological Sciences or equivalent, industry and nucleic acid medicine experience preferred. The title and compensation are commensurate with experience.
  • Hands-on experience with producing at least one type of nucleic acid delivery vehicles (liposomes, lipid nanoparticle, polymers, and exosome) and familiar with targeting technology including peptides, lipids, ligands, aptamers, etc.
  • Experience with methods to adjust the concentrations of vehicles to proper levels (dialysis, centrifugation and TFF) and storage conditions is required.
  • Experience with various formulation characterization methodologies is required, including size, charge, uniformity, endotoxin contains, encapsulation efficiency. Knowledge of purification of the vehicles and standard formulation stability requirement is desired.
  • Strong collaboration, problem solving, attention to details and communication skills.
    Strong skills in documentation and timeline management.

Molecular Axiom is an equal opportunity employer. All aspects of employment including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Tagged as: nucleic acid delivery scientist

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