Hope Changes Lives
You will join a dynamic team of scientists in our Oncology Translational Sciences Tumor Biology Group, playing a lead role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.
You will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to signal transduction, targeted therapeutics, and epigenetics. You will characterize and develop large and small molecules in close collaboration with partner lines as an integral member of the drug discovery teams. You will employ and develop cutting edge in vivo mouse and human cancer models. You will provide technical and scientific expertise in in vivo Pharmacology across ORD to enable target identification, validation, prioritization, and efficient drug discovery.
Plan, execute and analyze in vivo pharmacology studies.
Characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse models (GEMMs), to study biologic mechanisms and support exploration of novel therapies.
Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Perform ancillary in vitro and ex vivo assays to characterize effects of experimental medicines that may include Western Blot, scRNAseq or other assays as needed.
Quality documentation and interpretation of experimental results
Presentation of results within a multidisciplinary team environment.
Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards.
Bachelor’s degree in Biology/Tumor Biology/Oncology or similar discipline, with 6+ years relevant experience
Current knowledge of Oncology research, drug discovery, and development
Experience with animal models of human cancers. Hands on in vivo skills (IV, PO, SC, IP dosing), blood/tissue collection
Experience following novel scientific or technological developments, and implementing them in the laboratory.
Excellent written and oral communication and presentation skills
Experience integrating biological concepts into experimental design
Ex vivo skills such as Western blot is a plus
Experience with GraphPad Prism and/or Studylog is a plus
Industry experience preferred
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
Must be able to wear specialized protective clothing and PPE (lab coat, safety shoes/glasses/etc)
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Must be willing and able to work after hours as needed to ensure study integrity
Relocation support available