Hope Changes Lives
What You Will Achieve
At Pfizer we deliver breakthroughs that change patients’ lives. The Integrative Biotechnologies team plays a vital role in this mission through enabling the discovery and molecular understanding of large-molecule therapeutics. In La Jolla, we are dedicated towards redirecting the immune system against cancer through the application of engineered antibodies and cytokines. We are seeking inquisitive colleagues with expertise in cell biology, drug discovery, and high throughput screening (HTS).
As a Senior Associate Scientist, your research will uncover Pfizer’s next oncology therapeutics. Relevant activities include, but are not limited to design and development of cell-based assays, liquid handling and automation, and cell signaling mechanism-of-action studies.
The successful candidate will work closely with individuals in protein design and oncology groups to innovate and develop the next-generation of immunotherapies.
How You Will Achieve It
To enable therapeutic antibody discovery through in vitro cell-based assays.
To operate liquid handling and automation.
To analyze, organize, and present results in small and large group meetings.
To read relevant scientific literature to aid in experimental design.
Communicate experimental findings accurately in both oral and written formats.
To contribute to a dynamic, exciting culture that embraces teamwork and innovation.
B.S. degree with 3+ years’ experience in the fields of biology, biochemistry, or similar.
Proficiency in mammalian cell culture.
Experience with cell-based assays including assessment of transcriptional (qPCR, luciferase reporters), protein interactions (NanoBRET, complementation), cell viability, HTRF/ELISA, cell binding (FACS, imaging), and cytokine release (MSD, Luminex).
Ability to independently design, plan, execute, and interpret experiments.
M.S. degree with 1+ years’ experience
Basic knowledge of immunology
Experience using flow cytometers
Expertise in plasmid design, cloning, lentivirus, and generation of stable cell lines
Proficiency with SnapGene or similar molecular biology software
Familiarity with drug discovery, automation, and HTS.
Lifting, sitting, standing, walking, bending, ability to use pipette and operate general biology lab equipment, ability to perform mathematical calculations and data analysis related to biology experiments.
Other Job Details
Work Location Assignment: On Premise. On Premise colleagues work in a Pfizer site because it’s needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.