Research Scientist/Senior Research Scientist, Liver- targeted Gene Therapy

Poseida Therapeutics

Cell and Gene Therapy Biotech

Position Summary

Poseida Therapeutics s seeking a talented and self-motivated scientist/senior scientist to join our Gene Therapy team. This position offers an excellent opportunity for a highly motivated individual to develop new gene editing and gene therapy products in an exciting and dynamic environment focused on cutting-edge gene editing technology directed toward discovery and characterization of novel in vivo gene therapies.



These may include but are not limited to:

·       Use our proprietary gene therapy platform technologies to create new human therapeutic candidates directed at the liver

·       Evaluate diverse approaches to optimize gene editing and gene transfer into primary hepatocytes and in vivo, including preclinical animal models of disease

·       Analyze data and report to multidisciplinary groups

·       Attend scientific meetings, evaluate research findings and present results

·       Keep current on trends, new products and technologies in the gene therapy and gene editing fields

·       May manage 1-2 Research Technicians or Research Associates


Requirements, Knowledge, Skills and Abilities

·       PhD or equivalent in molecular biology, cell biology, pharmacology, toxicology, immunology or other relevant field with a minimum of 2 years’ of experience at Scientist level or minimum of 5 years’ experience at Senior Scientist level (a combination of education and experience may be considered).

·       Established publication record and deep understanding of their field.

·       Expertise with in vitro cell based assays and/or in vivo murine models is highly desirable.

·       Prior experience in primary cell isolation and culture of human and murine hepatocytes is desirable.

·       Extensive experience is preferred within at least one of the following fields: AAV vector construction & manufacture, cell product development, gene editing, integration site analysis, in vivo gene delivery.

·       Experience with various endpoint assays (qPCR and/or ddPCR, immune-staining (IHC/IFC), immunoassays and Western blot) is preferred.

·       Well principled in pharmacokinetic and toxicological study in the contexts of drug development.

·       Ability to document, organize, communicate and present complex data sets to key stakeholders from diverse backgrounds.

·       Capability to multi-task, be independent, self-motivated, as well as work in a highly collaborative setting.

·       Excellent oral and communication skills.

·       Exceptional critical thinking with analytic skills and trouble-shooting ability.


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