Senior Process Development Associate – Early Stage Process Development

Poseida Therapeutics

Cell and Gene Therapy Biotech

Position Summary

Poseida is seeking a highly motivated and collaborative individual to join our Early Process Development team. This position will work closely with the R&D and Tech Ops teams to develop, optimize, qualify, and integrate next generation processes and technologies for cell and gene therapy, focusing on allogeneic CAR-T cells. He/she will contribute to researching, developing, and implementing new methods and technologies to improve production as well as product characterization. He/she will be expected to complete scientific and technical tasks on aggressive timelines. Position requires excellent communication and presentation skills, a proven ability to plan and carry out experiments independently, troubleshoot technical issues, and to work with automation instrumentation and software.

 

Responsibilities

These may include but are not limited to:

 

·       Evaluate alternative technologies to create robust, reproducible, and scalable next generation manufacturing processes

·       Independently design and execute process development and product characterization studies. Experience with Design of Experiment (DoE) a plus

·       Document laboratory procedures and experiments with great attention to detail in laboratory notebooks

·       Analyze and present results in team and cross-functional meetings

·       Assist in the development of standard operating procedures, analytical test methods, analytical sampling plans, and technology transfer to internal or external manufacturers

·       Work with R&D teams to gain deeper understanding of process challenges and process-to-process product quality attribute variability

 

Requirements, Knowledge, Skills and Abilities

·       BS or MS degree in a scientific discipline (chemistry, biology, immunology or related field) with 5 plus years of experience

·       Demonstrated excellent aseptic technique. Proficient in cell culture of human cell lines and human primary cells

·       Hands-on experience in performing assays using human whole blood, PBMCs and purified T cell, such as multi-color immuno-phenotyping and lymphocyte subset characterization using flow cytometer, functional analysis of immune T cells such as cytotoxicity and ELISA assays

·       Demonstrated ability to troubleshoot, optimize and solve challenging research problems

·       Must be a creative, passionate, organized and detail-oriented person with excellent verbal and written communications skills

·       Adequate understanding and knowledge of immunology and CAR-T cell therapy

·       Experience in several of the following areas preferred: CAR-T cell therapy, product development, process characterization, scale-up, cGMP clinical manufacturing, cell separation by magnetic beads, automation, Design of Experiment (DOE), and/or technology transfer

 

Apply today at: https://recruiting.paylocity.com/recruiting/jobs/Apply/451498/Poseida-Therapeutics-Inc/Senior-Process-Development-Associate—Early-Stage-Process-Development

Tagged as: process development

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