Staff Scientist

Scripps Research

ABOUT US: Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences, and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Scientists in the institute’s five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advances in digital and precision medicine. Together, we cultivate new scientific leaders and expand the frontiers of knowledge to deliver medical breakthroughs to better human health around the globe. If you have a passion for making a difference, this could be your opportunity to join our transformative team.
Position Title: Staff Scientist
Position Summary:
The Staff Scientist will report to an Assistant Professor in the Chemistry Department cell and molecular biology to join a collaborative and interdisciplinary team of scientists focused on small molecule discovery and early-stage translational research. The staff scientist will provide effective scientific experimentation in: rodent handling; drug dosing; mammalian cell culture; drug discovery; mechanism of action studies; gene expression profiling; DNA purification or cloning; protein purification and characterization; enzymology; and HTS. Will also be responsible for accurate scientific research, documentation of results, and the evaluation/analysis of data and perform other related duties, tasks and responsibilities as required or assigned.
Duties and Responsibilities:
Lead the cellular biological and physiological components of a drug discovery project focused on oncological indications, specifically liquid tumors.
Profile small molecule analogs for potency in miniaturized assays of cell growth and differentiation
Establish and perform tumor xenograft models in the mouse
Perform complex cellular biological experiments to deconvolute the mechanism of action of identified lead molecules
Effectively communicate and collaborate with chemists and pharmacologists at Calibr and the Chemistry Department
Create accurate and timely reports of drug potency in miniaturized format
Effectively convey results in oral presentations with the research group
Ph.D. in the biological or chemical biological sciences preferably in Cancer biology, Molecular biology or Cell biology required.
A minimum of 2 years postdoctoral experience. Must be able to follow detailed instructions in the performance of experiments.
Must be able to interpret results.
Experience with mammalian cell culture techniques absolutely required.
Experience with Western blot analysis and qRT PCR analysis absolutely required.
Experience handling rodents required
Lentivirus production experience.
Cell and biochemical assay development and miniaturization experience.
Basic understanding of organic chemistry, microscopy and flow cytometry.
Ability to work independently and as part of a team while being collaborative in resolving problems.
Excellent organizational skills, problem solving skills and attention to detail.
Excellent oral and written communication skills.
​Physical Requirements: This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
Location: La Jolla, California 
Compensation: Salary is commensurate with experience.
The above statements describe the level of work performed and expected in general terms.  The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice.   Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. 
EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply.
COVID-19 update: 
The safety and well-being of our candidates, our people and their families continues to be a top priority. Until restrictions change, interviews will be conducted virtually.

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