Scientist/Sr. Scientist, Formulation Development

Seawolf Therapeutics is an early-stage venture-backed gene therapy company based in San Diego, CA.  We are an innovative and collaborative team set to transform the current landscape of therapeutics by developing next-generation non-viral genetic medicines that will be first-in-class and best-in-class therapeutics for patients living with rare diseases.  Come join our team and be an agent of change.


Position Summary:

We are seeking a talented formulation scientist to be a key member of the platform development team, to enable discovery research and development efforts.  This individual will be actively engaged in the design and development of the core delivery technology for advanced nucleic acid-based therapeutics.  The ideal candidate will have a proven ability to develop highly intricate lipid-based nano-formulations, including optimization and troubleshooting of the formulation process and exploration of novel materials.  Previous experience with formulations of lipid nanoparticles for the delivery of nucleic acid-based pharmaceuticals is strongly desired.  The ideal candidate is expected to be a strong collaborator who enjoys scientific discovery, has a passion for working on cutting-edge technology, and can communicate effectively in a fast-paced, dynamic, and interdisciplinary environment.



·        Support the design and development of unique and novel nucleic acid-based formulations

·        Characterize product profiles for process optimization and batch-to-batch reproducibility

·        Maintain meticulous documentation of all experimental data, procedures, and protocols

·        Review and analyze data and be able to present and explain across the functional teams

·        Collaborate with a team of scientists to creatively solve problems and drive innovation

·        Maintain high standards for scientific integrity and accountability

·        Communicate across departments and support project teams

·        Eventually manage, supervise and mentor 1-3 junior Scientists and/or Research Associates as the company evolves



·        PhD in related discipline (Scientist) with 3+ years (Sr. Scientist) relevant industry experience

    •    BS/MS with additional years of industry experience also acceptable

·        Hands on experience with the following:

    • Nano-formulation of nucleic acid-based therapeutics, filtration techniques, characterization of nanoparticulate matter
    • Experience with HPLC, UV-Vis, plate-based fluorescence assays

·                  Able to conduct self-directed research and thrive in a dynamic and fast-paced entrepreneurial setting with a diverse team of coworkers

·                  Exceptional problem-solving skills, outstanding interpersonal skills, creativity, enthusiasm, reliability, and attention to detail

·                  Capacity to supervise and mentor 1-3 junior Scientists and/or Research Associates

·                  Scientifically curious, paired with a strong work ethic and grit

·                  Open-minded, respectful of others, and a strong proponent of an inclusive culture

·                  Embraces the lean start-up mentality and is willing to wear multiple hats

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